Human pluripotency: A difficult state to make smart choices
نویسندگان
چکیده
منابع مشابه
The Current State of Naïve Human Pluripotency
Naïve or ground state pluripotency is a cellular state in vitro which resembles cells of the preimplantation epiblast in vivo. This state was first observed in mouse embryonic stem cells and is characterized by high rates of proliferation, the ability to differentiate widely, and global hypomethylation. Human pluripotent stem cells (hPSCs) correspond to a later or "primed" stage of embryonic de...
متن کاملLearning to make risk neutral choices in a symmetric world
Given their reference point, most people tend to be risk averse over gains and risk seeking over losses. Therefore, they exhibit a dual risk attitude which is reference dependent. This paper considers an adaptive process for choice under risk such that, in spite of a permanent short-run dual risk attitude, the agent eventually learns to make risk neutral choices. The adaptive process is based o...
متن کاملMapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiation toward desired fates. To this end, here, we map bifurcating lineage choices leading from pluripotency to 12 human mesodermal lineages, including bone, muscle, and hea...
متن کاملA Simulation-Optimization Model For Capacity Coordination In Make To Stock/Make To Order Production Environments
Capacity coordination, as the tactical level of hierarchical production planning in hybrid MTS/MTO systems, includes numerous important decisions. In this paper, two of these decisions i.e. finding the best strategy for the acceptance/rejection of incoming orders and determining orders’ due dates – are investigated. Also a simulation model is proposed to evaluate the efficiency of the presented...
متن کاملA Batch-wise ATP Procedure in Hybrid Make-to-Order/Make-to-Stock Manufacturing Environment
Satisfying customer demand necessitates manufacturers understanding the importance of Available-To-Promise (ATP). It directly links available resources to customer orders and has significant impact on overall performance of a supply chain. In this paper, an improvement of the batch-mode ATP function in which the partial fulfillment of the orders is available will be proposed. In other words, in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.20801